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SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 100 mg curcuminoids)
553 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic Blend Bifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
High relevance to cardiovascular research
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Read More
8
Curcumin improves lipid profiles
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
Highly relevant to cardiovascular health.
We explored the impact of curcumin, a component found in turmeric, on lipid profiles that are crucial for cardiovascular health. Our analysis reviewed 26 systematic reviews and meta-analyses involving 72 randomized controlled trials, focusing on how curcumin supplementation affects levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in the body.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
Read More
8
Inhaled turmerone protects aorta
Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta.
Directly examines turmeric's effects
We explored the effects of inhaled turmerone, a compound found in turmeric, on the degeneration of the aorta caused by nicotine. This research is significant because nicotine from secondhand smoke is known to increase the risk of cardiovascular disease. Our study focused on understanding how inhaled turmerone might counteract these harmful effects.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
Read More
Most Useful Reviews
8.8
Reduces inflammation
Curcumin is exceptional! I sought a suitable curcumin for some time. Its benefits include reducing chronic inflammation, crucial for preventing metabolic disorders and cardiovascular disease. It also helps arthritis sufferers by alleviating joint swelling. I chose this one for its effective dosage and the presence of pepper and ginger, though the tablets are a bit large, they are still manageable to swallow.
Read More
8
Pain relief achieved
Great quality! I took this supplement for sore joints due to my inability to use anti-inflammatories from my duodenum and gallbladder issues. After three months, my big toe joint pain has completely dissipated, my complexion has improved, and I haven't taken omeprazole for four months. I will continue with this product!
Read More
8.8
No surgery needed
I ordered this curcumin for my father with advanced varicose veins, and thankfully, surgery was avoided. I began taking it during COVID-19 to thin my blood. After six months, my blood was sufficiently thin. I even give some to my three-year-old with a cold. It’s vital for our family, especially during cold seasons.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
9
Curcumin protects heart cells effectively
Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling.
Study highlights turmeric's heart benefits
We investigated curcumin, a compound derived from turmeric, and its ability to protect heart cells from damage caused by conditions like myocardial ischemia and reperfusion injury (MIRI). Utilizing a model involving Sprague-Dawley rats and heart cells subjected to anoxia and reoxygenation, we aimed to understand how curcumin affects heart health at a cellular level.
During the experiments, we observed that curcumin significantly reduced MIRI effects. It improved heart tissue structure, increased the viability of heart cells, and inhibited processes related to cell death, specifically ferroptosis, apoptosis, and autophagy. Furthermore, curcumin helped reduce the size of heart tissue damage and preserved overall heart function.
Our findings indicated that MIRI disrupts important protein pathways, leading to cell death by activating autophagy-related genes. However, curcumin appeared to counteract this by activating protective signaling pathways that inhibit these harmful processes. We noted that blocking the action of curcumin nullified its protective effects, underscoring its significance as a heart-protective agent.
Overall, our research supports the idea that curcumin may play a valuable role in safeguarding cardiovascular health, especially under stress conditions like ischemia-reperfusion injury.
During the experiments, we observed that curcumin significantly reduced MIRI effects. It improved heart tissue structure, increased the viability of heart cells, and inhibited processes related to cell death, specifically ferroptosis, apoptosis, and autophagy. Furthermore, curcumin helped reduce the size of heart tissue damage and preserved overall heart function.
Our findings indicated that MIRI disrupts important protein pathways, leading to cell death by activating autophagy-related genes. However, curcumin appeared to counteract this by activating protective signaling pathways that inhibit these harmful processes. We noted that blocking the action of curcumin nullified its protective effects, underscoring its significance as a heart-protective agent.
Overall, our research supports the idea that curcumin may play a valuable role in safeguarding cardiovascular health, especially under stress conditions like ischemia-reperfusion injury.
Read More
9
Curcumin shows promise for heart health
Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model.
Combining curcumin with ISO limits conclusions
We explored the effects of dendrosomal nano-curcumin, a form of curcumin derived from turmeric, on cardiac fibrosis—a major contributor to heart disease. The study utilized both laboratory and animal models to test how well this treatment could counteract damage caused by isoproterenol (ISO), a substance known to induce cardiac fibrosis.
Our observations indicated that when heart cells were treated with ISO to promote fibrosis, the addition of dendrosomal nano-curcumin helped reduce this fibrotic effect. We noted similar positive outcomes in live mouse models where ISO induced heart and lung fibrosis, resulting in the expression of genes linked to inflammation and fibrosis. The application of nano-curcumin before, during, or after ISO treatment showed promise in mitigating these damaging effects.
Furthermore, through advanced RNA sequencing, we identified a gene called COMP that was expressed differently following fibrosis induction, suggesting it could serve as a new marker in understanding heart conditions. Overall, our findings point towards the potential of dendrosomal nano-curcumin as both a preventive and therapeutic agent for heart complications linked to fibrosis.
Our observations indicated that when heart cells were treated with ISO to promote fibrosis, the addition of dendrosomal nano-curcumin helped reduce this fibrotic effect. We noted similar positive outcomes in live mouse models where ISO induced heart and lung fibrosis, resulting in the expression of genes linked to inflammation and fibrosis. The application of nano-curcumin before, during, or after ISO treatment showed promise in mitigating these damaging effects.
Furthermore, through advanced RNA sequencing, we identified a gene called COMP that was expressed differently following fibrosis induction, suggesting it could serve as a new marker in understanding heart conditions. Overall, our findings point towards the potential of dendrosomal nano-curcumin as both a preventive and therapeutic agent for heart complications linked to fibrosis.
Read More
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
High relevance to cardiovascular research
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Read More
8
Inhaled turmerone protects aorta
Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta.
Directly examines turmeric's effects
We explored the effects of inhaled turmerone, a compound found in turmeric, on the degeneration of the aorta caused by nicotine. This research is significant because nicotine from secondhand smoke is known to increase the risk of cardiovascular disease. Our study focused on understanding how inhaled turmerone might counteract these harmful effects.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
Read More
8
Curcumin improves lipid profiles
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
Highly relevant to cardiovascular health.
We explored the impact of curcumin, a component found in turmeric, on lipid profiles that are crucial for cardiovascular health. Our analysis reviewed 26 systematic reviews and meta-analyses involving 72 randomized controlled trials, focusing on how curcumin supplementation affects levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in the body.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.5
8.8
Reduces inflammation
Curcumin is exceptional! I sought a suitable curcumin for some time. Its benefits include reducing chronic inflammation, crucial for preventing metabolic disorders and cardiovascular disease. It also helps arthritis sufferers by alleviating joint swelling. I chose this one for its effective dosage and the presence of pepper and ginger, though the tablets are a bit large, they are still manageable to swallow.
Read More
8.8
Enhances brain function
Turmeric possesses antioxidant properties, boosts brain function, and reduces the risk of cardiovascular disease and cancer. It's beneficial for Alzheimer's prevention, arthritis, depression, and even slows ageing. The black pepper improves turmeric absorption. I greatly appreciate the Garden of Life brand and am satisfied with my purchase.
Read More
8.8
No surgery needed
I ordered this curcumin for my father with advanced varicose veins, and thankfully, surgery was avoided. I began taking it during COVID-19 to thin my blood. After six months, my blood was sufficiently thin. I even give some to my three-year-old with a cold. It’s vital for our family, especially during cold seasons.
Read More
8.8
Relieves joint pain
Curcumin is a remarkable antioxidant! My family uses it for various ailments, particularly for liver function disorders and cardiovascular disease. It alleviates pain and inflammation in my joints. The brand’s quality is high; I noticed its benefits immediately. I recommend it for anyone needing positive results!
Read More
8.8
Improves immunity
After a health issue, my doctor advised turmeric, and I selected this excellent product. Turmeric aids in inflammation relief and arthritis pain. It improves metabolism and helps detoxify the body, boosting immunity and overall well-being. I even bought it in marmalade form for children.
Read More
